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Infant formula is a food manufactured to support the great adequate growth of infants under six months of age when fed as a sole source of nutrition[1]. The composition of infant formula is roughly based on a mother's milk at approximately one to three months postpartum[2]. The most commonly used infant formulas contain purified cow's milk whey and casein as a protein source, a blend of vegetable oils as a fat source, lactose as a carbohydrate source, a vitamin-mineral mix, and other ingredients depending on the manufacturer[3]. In addition, there are infant formulas using soya bean as a protein source in place of cow's milk (mostly in the United States and Great Britain) and formulas using protein reduced (hydrolysed) into its component amino acids for infants who are allergic to other proteins. An upswing in breastfeeding has been accompanied by a deferment in the average age of introduction of other foods (such as cow's milk), resulting in increased use of both breastfeeding and infant formula between the ages of 3–12 months.[4][5]

A 2001 WHO report finds that infant formula prepared in accord with applicable Codex Alimentarius standards is a nutritionally adequate and safe complementary food and a suitable breast milk substitute. Nonetheless, with few exceptions the WHO report recommends exclusive breastfeeding for the first 6 months of life for all babies.[6]

Infant formula is necessarily an imperfect approximation of breast milk because:

* The exact chemical properties of breast milk are not fully understood.[7]
* A mother's breast milk changes in response to the feeding habits of her baby and over time, thus adjusting to the infant's individual growth and development.[8]
* Breast milk includes a mother's antibodies that help the baby avoid or fight off infections and give his immature immune system the benefit of his mother's immune system that has many years of experience with the germs common in their environment.


* 1 History of formula
o 1.1 Early infant foods
o 1.2 Raw milk formulas
o 1.3 Evaporated milk formulas
o 1.4 Commercial formulas
o 1.5 Store brand (generic) infant formulas
o 1.6 Follow-on and toddler formulas
o 1.7 Usage since 1970s
* 2 Reasons to use infant formula
* 3 Nutritional content
o 3.1 Other Ingredients
* 4 Variations
* 5 Preparation
* 6 Controversy and science
o 6.1 Use
o 6.2 Ethnicity
o 6.3 Nutritional value
o 6.4 Toxins
o 6.5 Health effects
o 6.6 Melamine contamination
o 6.7 Other controversies
o 6.8 Risks decreased
+ 6.8.1 Decreased by alternative to breastfeeding by the mother
+ 6.8.2 Risks decreased by formula-feeding specifically
o 6.9 Balancing risks
* 7 Industry
o 7.1 Manufacturers
o 7.2 Market size
o 7.3 Government subsidies
+ 7.3.1 United States
o 7.4 Marketing
+ 7.4.1 United States
+ 7.4.2 United Kingdom
o 7.5 By country
+ 7.5.1 Philippines
+ 7.5.2 Canada
* 8 Infant Formula Processing
o 8.1 History of Infant Formula Development
o 8.2 Current general procedure for infant formula processing
+ 8.2.1 Mixing ingredients
+ 8.2.2 Pasteurization
+ 8.2.3 Homogenization
+ 8.2.4 Standardization
+ 8.2.5 Packaging
+ 8.2.6 Heat Treatment/Sterilization
o 8.3 Recent and future potential new ingredients
+ 8.3.1 Probiotics
+ 8.3.2 Prebiotics
+ 8.3.3 Lysozyme and Lactoferrin
* 9 See also
* 10 References
* 11 External links

[edit] History of formula
[edit] Early infant foods

Throughout history, mothers who could not breastfeed their babies either employed the use of a wet nurse[9] or, less frequently, prepared food for their babies, a process known as "dry nursing."[9][10] Baby food composition varied according to region and economic status.[10] In Europe and America during the early 19th century, the prevalence of wet nursing began to decrease, while the practice of feeding babies mixtures based on animal milk rose in popularity.[11][12]
Poster advertisement for Nestle's Milk by Théophile Alexandre Steinlen, 1895

This trend was driven by cultural changes as well as increased sanitation measures,[13] and it continued throughout the 19th and much of the 20th century, with a notable increase after Elijah Pratt invented and patented the India-rubber nipple in 1845.[9][14] As early as 1846, scientists and nutritionists noted an increase in medical problems and infant mortality was associated with dry nursing.[11][15] In an attempt to improve the quality of manufactured baby foods, in 1867, Justus von Liebig developed the world's first commercial infant formula, Liebig's Soluble Food for Babies.[16] The success of this product quickly gave rise to competitors such as Mellin's Infant Food, Ridge's Food for Infants and Nestle's Milk.[17]
[edit] Raw milk formulas

As physicians became increasingly concerned about the quality of such foods, medical recommendations such as Thomas Morgan Rotch's "percentage method" (published in 1890) began to be distributed, and gained widespread popularity by 1907.[9] These complex formulas recommended that parents mix cow's milk, water, cream, and sugar or honey in specific ratios to achieve the nutritional balance believed to approximate human milk reformulated in such a way as to accommodate the believed digestive capability of the infant.[4]

At the dawn of the 20th century in the United States, most infants were breastfed, although many received some formula feeding as well. Home-made "percentage method" formulas were more commonly used than commercial formulas in both Europe and the United States.[18] They were less expensive and were widely believed to be healthier. However, formula-fed babies exhibited more diet-associated medical problems, such as scurvy, rickets and bacterial infections than breastfed babies. By 1920, the incidence of scurvy and rickets in formula-fed babies had greatly decreased through the addition of orange juice and cod liver oil to home-made formulas. Bacterial infections associated with formula remained a problem more prevalent in the United States than in Europe, where milk was usually boiled prior to use in formulas.[18]
[edit] Evaporated milk formulas

In the 1920s and 1930s, evaporated milk began to be widely commercially available at low prices, and several clinical studies suggested that babies fed evaporated milk formula thrive as well as breastfed babies[9][19] (these findings are not supported by modern research). These studies, accompanied by the affordable price of evaporated milk and the availability of the home icebox initiated a tremendous rise in the use of evaporated milk formulas.[4] By the late 1930s, the use of evaporated milk formulas in the United States surpassed all commercial formulas, and by 1950 over half of all babies in the United States were reared on such formulas.[9]
[edit] Commercial formulas

In parallel with the enormous shift (in industrialized nations) away from breastfeeding to home-made formulas, nutrition scientists continued to analyze human milk and attempted to make infant formulas that more closely matched its composition.[4] Maltose and dextrins were believed nutritionally important, and in 1912, the Mead Johnson Company released a milk additive called Dextri-Maltose. This formula was made available to mothers only by physicians. In 1919, milkfats were replaced with a blend of animal and vegetable fats as part of the continued drive to closer simulate human milk. This formula was called SMA for "simulated milk adapted."[9]

In the late 1920s, Alfred Bosworth released Similac (for "similar to lactation"), and Mead Johnson released Sobee.[9] Several other formulas were released over the next few decades, but commercial formulas did not begin to seriously compete with evaporated milk formulas until the 1950s. The reformulation and concentration of Similac in 1951, and the introduction (by Mead Johnson) of Enfamil in 1959 were accompanied by marketing campaigns that provided inexpensive formula to hospitals and pediatricians.[9] By the early 1960s, commercial formulas were more commonly used than evaporated milk formulas, which all but vanished in the 1970s. By the early 1970s, over 75% of babies in the United States were fed on formulas, almost entirely commercially produced.[4]

When birth rates in industrial nations tapered off during the 1960s, infant formula companies heightened marketing campaigns in non-industrialized countries. Unfortunately, poor sanitation led to steeply increased mortality rates among infants fed formula prepared with contaminated (drinking) water.[20] Organized protests, the most famous of which was the Nestlé boycott of 1977, called for an end to unethical marketing. This boycott is ongoing, as the current coordinators maintain that Nestlé engages in marketing practices which violate the International Code of Marketing of Breast-milk Substitutes.
[edit] Store brand (generic) infant formulas

Store brand infant formula was first introduced in the United States in 1997 by PBM Products. All infant formula brands in the United States are required to adhere to the U.S. Food and Drug Administration (FDA) guidelines.

The Mayo Clinic said, “As with most consumer products, brand-name infant formulas cost more than generic brands. But that doesn't mean that brand-name [Similac, Nestle, Enfamil] formulas are better. Although manufacturers may vary somewhat in their formula recipes, the FDA requires that all formulas contain the same nutrient density.”[21]

Private label infant formulas have allowed the leading food and drug retailers to provide formula to customers that is labeled under the store brands of companies such as Wal-Mart, Target, Kroger, Loblaws, and Walgreens.
[edit] Follow-on and toddler formulas

In the 1980s and 1990s, formula was introduced for older children, up to the age of 2 years, under such terms as "follow-on formula" and "toddler formula". This was done partly because the market for infant formula (strictly speaking, up to age 6 months, when infants typically exclusively breastfeed) was saturated in developed countries, as discussed in industry, below, and in conjunction with regulations on infant formula advertising. Critics have argued that follow-on and toddler formulas were introduced partly to circumvent these regulations – advertising for similarly packaged and branded follow-on formula is often interpreted as advertising for infant formula targeted at under 6 month-olds.

An early example of follow-on formula was introduced by Wyeth in the Philippines in 1987, following the introduction in this country of regulations on infant formula advertising, which regulations did not address follow-on formula, which did not exist at the time of their drafting.[22]
[edit] Usage since 1970s

Since the early 1970s, industrial countries have witnessed a dramatic resurgence in breastfeeding among children from newborn to 6 months of age.[5] However, this upswing in breastfeeding has been accompanied by a deferment in the average age of introduction of other foods (such as cow's milk), resulting in increased use of both breastfeeding and infant formula between the ages of 3–12 months.[4][5]

Leading health organizations (e.g. US CDC, WHO, US HHS) are attempting to increase the prevalence of breastfeeding through public awareness campaigns.[23][24][25] The goals of these programs vary by organization, with recommended breastfeeding ages ranging between birth and 24 months.[26] Additionally, regulatory initiatives also encourage breastfeeding. For example, the International Code of Marketing of Breast-milk Substitutes requires infant formula companies to preface their product information with statements that breastfeeding is the best way of feeding babies and that a substitute should only be used after consultation with health professionals.[27]
[edit] Reasons to use infant formula

There are few medical reasons to use infant formula – "The vast majority of mothers can and should breastfeed, just as the vast majority of infants can and should be breastfed," and "Only under exceptional circumstances can a mother's milk be considered unsuitable for her infant."[6][28] Alternatives to breast-feeding include:

* expressed breast milk from an infant’s own mother,
* breast milk from a healthy wet nurse,
* breast milk from a human-milk bank,

as well as infant formula.[6] Among these, the WHO states that "the choice of the best alternative ... depends on individual circumstances."[6]

Reasons to not breastfeed or it is not possible to breastfeed include:

* The mother's health: The mother is infected with HIV[29] or tuberculosis.[29] She is malnourished or has had certain kinds of breast surgery. She is taking any kind of drug that could harm the baby,[29] or drinks unsafe levels of alcohol. The mother is extremely ill.
* The baby is unable to breastfeed: The child has a birth defect or inborn error of metabolism such as galactosemia that makes breastfeeding difficult or impossible.
* Absence of the mother: The child is adopted, orphaned, or in the sole custody of a man. The mother is separated from her child by being in prison or a mental hospital. The mother has left the child in the care of another person for an extended period of time, such as while traveling or working abroad. The mother has abandoned the child.
* Financial pressures: Maternity leave is unpaid, insufficient, or lacking. The mother's employment interferes with breastfeeding.
* Societal structure: Breastfeeding is difficult or forbidden at the mother's job, school, place of worship or while commuting.
* Social discomfort: The mother may feel uncomfortable breastfeeding around other people.
* Personal beliefs: The mother may choose to not breastfeed for varied personal reasons – for instance, she may feel that breasts are too sexual for a baby.
* Lack of training: The mother is not trained sufficiently to breastfeed without pain and to produce enough milk.
* Dietary concerns: The contents of breastmilk are influenced by the dietary habits of the mother. If the mother consumes a food that contains an allergen breastfeeding may, for a brief period after consumption, provoke an allergic reaction in the infant.

Reasons to supplement by alternatives, in addition to breastfeeding, include:

* Social structure or discomfort: The mother may be able to breastfeed at some hours, but not at others, for reasons cited above.
* Lactation insufficiency: The mother is unable to produce sufficient milk, which affects around 2 to 5% of women.[30]

Reasons to use infant formula specifically, as opposed to the alternatives of expressed milk, wet nurses, and milk banks, include:

* Lack of education: The mother, her doctor,[31] or family may believes that her breast milk is of low quality or in low supply, or that breastfeeding will decrease her energy, health, or attractiveness, and be unaware of other alternatives. Nursing by a relative or paid wet-nurse may be believed to be unhygienic.
* Social pressures: Family members, such as mother's husband or boyfriend, or friends or other members of society may encourage the use of infant formula.
* Personal beliefs: The mother may choose to use formula for varied personal beliefs.
* Lack of alternatives:
o Lack of refrigeration: Expressed breast milk requires refrigeration if not immediately consumed, and sanitary preparation conditions – this latter requirement is shared with infant formula.
o Lack of wet nurses: Wet nursing is illegal and stigmatized in some countries, and may not be available.[32] It may also be socially unsupported or expensive, and safe use of wet nurses requires health screening of the nurses.
o Lack of milk banks: Human-milk banks may not be available; relatively few exist, and they require screening and refrigeration.

[edit] Nutritional content

Infant formula is nutritionally inferior to breast milk but superior to other substitutes such as animal milk. Besides breast milk, infant formula is the only other milk product which the medical community considers nutritionally acceptable for infants under the age of one year – note that solid food is nutritionally acceptable in addition to breast milk or formula during weaning.

Although cow's milk is the basis of almost all infant formula, plain cow's milk is unsuited for infants because of its high casein content and low whey content which may put a strain on an infant's immature kidneys, and untreated cow's milk is not recommended before the age of 12 months. The infant intestine is not properly equipped to digest non-human milk and this may often result in diarrhea, intestinal bleeding and malnutrition[citation needed]. To reduce the negative effect on the infants digestive system, cows milk used for formula undergoes processing in order to be made into infant formula. This includes steps in order to make protein more easily digestible and alter the whey-to-casein protein balance to a ratio closer to human milk, the addition of several essential ingredients (often called "fortification", see below), the partial or total replacement of dairy fat with fats of vegetable or marine origin, etc.

Most of the world's supply of infant formula is produced in the United States[citation needed]. The nutrient content of infant formula for sale in the United States is regulated by the American Food and Drug Administration (FDA) based on recommendations by the American Academy of Pediatrics Committee on Nutrition. The following must be included in all formulas produced in the U.S.:[33]

* Protein
* Fat
* Linoleic acid
* Vitamins: A, C, D, E, K, thiamin (B1), riboflavin (B2), B6, B12
* Niacin
* Folic acid
* Pantothenic acid
* Calcium
* Metals: magnesium, iron, zinc, manganese, copper
* Phosphorus
* Iodine
* Sodium chloride
* Potassium chloride
* Carbohydrates
o Carbohydrates are an important source of energy for growing infants as it accounts for 35 to 42% of their daily energy intake. In most cow's based formulas, lactose is the main source of carbohydrates present. But lactose is not present in cow's milk-based lactose-free formulas nor specialized non-milk protein formulas or hydrolyzed protein formulas for infants with milk protein sensitivity. Lactose is also not present in soy-based formulas. Therefore, those formulas without lactose will use other sources of carbohydrates like sucrose and glucose, natural and modified starches, monosacchardies and indigestible carbohydrates. Lactose is not only a good course of energy, it also aids in the absorption of various minerals like magnesium, calcium, zinc and iron.[34]

* Nucleotides
o Nucleotides are compounds found naturally in human breast milk. They are involved in many different critical metabolic processes in the body like energy metabolism and enzymatic reactions. Also, as the building blocks of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) they are essential for normal body functions. Compared to human breast milk, cow's milk has lower levels of nucleotides like uridine, inosine, and cytidine. Therefore, several companies that produce infant formula have added nucleotides to their infant formulas.[34]

[edit] Other Ingredients

* Emulsifiers and stabilizers

Emulsifiers and stabilizers are raw materials that are added to prevent the separation of the oil and water-soluble component in the infant formula. Some commonly used emulsifiers include mono, di-glycerides, and gums.[33]

* Diluent

The ingredient helps create the liquid bulkiness in infant formula. Skim milk is commonly used as the primary diluent in milk-based formulation. In contrast, purified water is the most commonly used diluent in milk-free formulations.[33]

In addition, formulas not made with cow's milk must include biotin, choline, and inositol.

Hypoallergenic formulas reduce the likelihood of certain medical complications in babies with specific health problems. Baby formula can be synthesized from raw amino acids. This kind of formula is sometimes referred to as elemental infant formula or as medical food because of its specialized nature. While quite expensive, such formula is hypoallergenic and is sometimes used for babies with severe allergies to cow's milk and soy. Some commercial brands are Neocate and Peptamen. Being purely synthetic monomeric amino acids, it is also quite foul-tasting to adults, and it is not uncommon for infants to reject elemental formulas after having been established on a sweeter tasting, non-elemental formula.
[edit] Variations

Infant formula is available in powder, liquid concentrate, and ready-to-feed forms.

Infant formulas come in a variety of types:

* Cow's milk formula - the "typical" most commonly used type.
* Soy protein based formulas - frequently used for infants allergic to cow's milk.
* Partially hydrolyzed formulas - (e.g.: Good Start® and Gentlease®)
* Extensively hydrolyzed formulas - (e.g.: Alimentum®, Nutramigen®, and Pregestimil®) are considered "hypoallergenic" and 90% of children with Cow's milk allergies will tolerate them.[35]
* Amino acid based formulas - (e.g.: Neocate®, EleCare®, and Nutramigen AA®) are more expensive, but the least likely to cause allergic reactions.[36]

Recently the market has been segmented by age into:[37]

* infant formula, up to 6 months,
* follow-on formula, from 6 months to 12 months,
* toddler formula, from 12 months on.

These categories and formulations may overlap, and there is substantial consumer confusion about these categories.[38]

These were introduced and developed partly to address the saturation of the infant formula market (up to 6 months) in developed countries, as discussed in industry, below, and partly due to regulations on infant formula, which often did not cover milk substitutes for children older than 6 months; an early example is Wyeth's introduction of follow-on formula in the Philippines in 1987, following introduction of regulations on infant formula marketing.[22] They have also result in confusing advertising – in the United Kingdom infant formula advertising is illegal, but follow-on formula advertising is legal, and the similar packaging and market results in follow-on advertisements frequently being interpreted as adverts for formula.[38]
[edit] Preparation

Infant formula should be prepared by the caregiver or parent in small batches and fed to the infant, usually with either a cup, as recommended by the WHO,[6] or a baby bottle.

It is very important to measure powders or concentrates accurately to achieve the intended final product, otherwise the child will be malnourished. It is advisable that all equipment that comes into contact with the infant formula be cleaned and sterilized before each use. Proper refrigeration is essential for any infant formula which is prepared in advance.

In developing countries, formula is frequently prepared improperly, resulting in high infant mortality due to malnutrition and diseases such as diarrhea and pneumonia. This is due to lack of clean water, lack of sterile conditions, lack of refrigeration, illiteracy (so written instructions cannot be followed), poverty (diluting formula so that it lasts longer), and lack of education of mothers by formula distributors.[39] These problems and resulting disease and death are a key factor in opposition to the marketing and distribution of infant formula in developing countries by numerous NGOs – these groups do not consider infant formula appropriate technology for developing countries.
[edit] Controversy and science

The use and marketing of infant formula has come under scrutiny; as discussed at breastfeeding, breast milk is considered the "ideal food" for babies, and the "ideal addition" to other foods, and exclusive breast feeding for the first 6 months of a baby's life is advocated by health authorities[6][26] and accordingly by infant formula manufactures.[40]
[edit] Use

Despite the recommendation that babies be exclusively breastfed for the first 6 months of life, the overwhelming majority of American babies are not exclusively breastfed for this period – in 2005 under 12% of babies were breastfed exclusively for the first 6 months,[26] with over 60% of babies of 2 months of age being fed formula,[41] and approximately one in four breastfed infant having infant formula feeding within two days of birth.[42]
[edit] Ethnicity

According to a research conducted in Vancouver, Canada, 1998, at birth, 82.9 % of mothers breastfeed their babies, but this number differs between Caucasians(91.6%) and Non-Caucasians(56.8%).[43]
[edit] Nutritional value

The WHO considers infant formula that is safely prepared and formulated in accord with the Codex Alimentarius a nutritionally adequate and safe complementary food.[6]
[edit] Toxins

Infant formula contains significantly higher levels of manganese than breast milk – 80 times as much in soy-derived, and 30 times as much in animal milk-derived. This level of manganese and its presence in infant formula has been implicated in learning disabilities such as ADHD.[44][45][46]
[edit] Health effects

Use of infant formula is cited in numerous health risks. Studies have found infants in developed countries who consume formula are at increased risk for acute otitis media, non-specific gastroenteritis, severe lower respiratory tract infections, atopic dermatitis, asthma, obesity, type 1 and 2 diabetes, sudden infant death syndrome (SIDS), eczema, necrotizing enterocolitis and autism when compared to infants who are breastfed.[47][48][49][50]

Although some early studies have found an association between infant formula and lower cognitive development,[51] other studies have found no correlation.[47] However recently more questions have arisen. It has been discovered that iron supplementation in baby formula is linked to lowered I.Q. and other neurodevelopmental delays.[52]
[edit] Melamine contamination
Main article: 2008 Chinese milk scandal

On November 25, 2008, an Associated Press article entitled, "FDA finds traces of melamine in US infant formula," explains infant formula made by the main three firms has tested positive for melamine contamination.[53] These three main firms are responsible for 90% of infant formula in the US, "Abbott Laboratories, Nestle and Mead Johnson."[54]

The MSDS for Melamine (CAS NO 108-78-1; C3-H6-N6) records the acute oral toxicity (LD50) at 3161 mg/kg (3161 ppm) for a rat. The highest levels previously reported in China reached approximately 2500 ppm. The article mentioned above indicated that the US testing found 10,000 times less than the China levels or 0.25 ppm.

Health Canada conducted a separate test and also detected traces of melamine in infant formula available in Canada. The melamine levels were well below Health Canada's safety limits, although some public health advocates are critical of the industry and regulators for allowing any residues of a potentially dangerous substance in food for infants.[55]

Health officials have been on alert for the chemical since the discovery this year of a massive case of melamine poisoning in China, where milk was deliberately adulterated with the chemical, leading to illnesses in more than 50,000 children, including cases of acute kidney failure. In China, large quantities of melamine were deliberately added to watered-down milk to give it the appearance of having adequate protein levels.[55]
[edit] Other controversies

* In 1985 Syntex was ordered to pay $27 million for the death of two infants who were given the Syntex baby formula, called Neo-mull-soy, when they were infants. In 1978, Syntex had eliminated salt from the formula.[56]

[edit] Risks decreased

Some risks are cited as being decreased when using alternatives to breastfeeding by the mother generally, or by using formula specifically.
[edit] Decreased by alternative to breastfeeding by the mother

Infectious diseases transmitted from the breastfeeder

The main risk posed by the mother's milk specifically is the transmission of infectious diseases such as HIV. In some cases these can be mitigated by using heat-treated milk and nursing for a briefer time (6 months, rather than 18–24 months), and can be avoid by using an uninfected woman's milk, as via a wet-nurse or milk bank, or by using formula, or treated animal milk.[57]

* HIV infection[58][59]

Breastfeeding by an HIV-infected mother poses a 5–20% chance of transmitting HIV to the baby, assuming [60]

* CMV infection,[58] with potentially dangerous consequences in pre-term babies[61]
* HTLV-1 infection[58][59]
* HTLV-2 infection[59]
* Tuberculosis in the context of tuberculosis mastitis
* Herpes simplex when lesions are present on the breasts[59]
* Chickenpox in the newborn, when the disease manifested in the mother within a few days of birth[59]

[edit] Risks decreased by formula-feeding specifically

Some risks are present in all breast milk, and are only mitigated by the use of infant formula.

Environmental contaminants

* Exposure to polybrominated diphenyl ethers (PBDEs)
* Exposure to polychlorinated biphenyls[62]


While in general breast milk is the "ideal food" for babies,[6] in certain circumstances or respects infants may be at risk for malnutrition.

* Iron deficiency
* Vitamin deficiencies

Particularly vitamin D in babies at high latitudes who lack sun exposure

* Inadequate nutrition during transition to solid foods[63]

[edit] Balancing risks

Weighing the risks, health authorities generally on balance judge breastfeeding the healthiest, least risky option, as follows:

* In cases where the mother has an infectious diseases such as HIV, exclusive breastfeeding is suggested until alternatives that satisfy the AFASS (Acceptable Feasible Affordable Sustainable and Safe) principles are available; such alternatives include breast milk from other women, infant formula, and treated animal milk.[57] In developing countries, risks from other sources of infant mortality such as diarrhea, particularly due to unclean water and lack of sterile conditions – both prerequisites to the safe use of formula – often outweigh risks from breastfeeding.

* The risks from pollution are not seen to outweigh the benefits of breastfeeding,[64][65] and "adverse effects on learning and behavior are strongly associated with fetal exposure to persistent pollutants, not with breast milk exposure".[44]

The WHO finds that neurological benefits of breast milk remain, regardless of the dioxin exposure from milk,[66] and other researchers conclude that the benefits of breastfeeding outweigh the danger posed by these toxins.[65]
[edit] Industry
Wiki letter w.svg This section requires expansion.
[edit] Manufacturers

The US infant formula industry is highly concentrated:[67] it is an oligopoly with 3 companies accounting for 99% of the market in 2000:[67]

* Mead Johnson: 52%, makes Enfamil, Pregestimil, Nutramigen, and Nutramigen AA
* Abbott Laboratories: 35%, Ross division makes Similac, Isomil, Alimentum, and EleCare
* Nestlé: 12%, the largest producer of formula in the world, makes Good Start; owns Gerber Products Company
* Wockhardt Nutrition:Emerging with brand like Farex1 and Farex2

Other infant formula manufacturers include:

* Danone recently acquired Royal Numico, Dumex, Milupa
* Earth's Best owned by Hain Celestial
* Natures One - privately held Ohio based company producing mostly organic formula for toddlers
* Novalac - a comprehensive range of infant formula present in more than 40 countries throughout the world
* Nutricia - maker of Neocate
* Wyeth Nutrition: Market leader in the Philippines

S-26 Gold, Promil Gold, Progress Gold, S-26, Promil, Promil Kid, Bonna, Bonamil, Bonakid 1+, Bonakid 3+, Nursoy, Parent's Choice/Bright Beginnings

[edit] Market size
Wiki letter w.svg This section requires expansion.

Infant formula is the largest segment of the baby food market,[68][69] with the fraction given as between 40%[68] and 70%.[69][70]

The global infant formula market is estimated at $7.9 billion.[70] North America and Western Europe are 33% of the market and saturated, while Asia is 53% of the market.[68] South East Asia is a particularly large fraction of the world market relative to its population.[68]
[edit] Government subsidies
[edit] United States

In the United States, infant formula is heavily subsidized by the government: at least one third of the US market is supported by the government,[70] with over half of infant formula in the US provided through WIC[67] – WIC is the US food aid program, not a medical program, which is Medicaid. Breastfeeding rates are substantially lower for WIC recipients;[71] this is partly attributed to formula being free of charge to WIC mothers, and partly to WIC recipients being poor and uneducated, hence less likely to breastfeed.[67] Further, some promotional materials use the WIC trademark, in violation of federal policy.[71] Infant formula costs are a significant fraction of WIC costs: 21% post-rebate, and 46% pre-rebate.[67] Formula manufacturers are granted a WIC monopoly in individual states – only one brand of formula will be eligible for WIC.[67]

WIC also pays for milk banks.[72][73]
[edit] Marketing
Wiki letter w.svg This section requires expansion.
See also: Nestle Boycott

Marketing of infant formula and the regulation thereof varies between countries.

The International Code of Marketing of Breast-milk Substitutes is a statement of principles regarding infant formula marketing, including strict restrictions on advertising. Its implementation depends on the laws of different countries and the behavior of infant formula manufacturers – the code has no power itself. Legislation and corporate behavior vary significantly between countries: in some countries the code is implemented in law and followed by formula manufacturers, while in others it is not.

Practices that are banned in the code include most advertising, claiming health benefits for formula, and giving free samples to women able to breastfeed – this latter practice is particularly criticized because it can interfere with lactation, creating dependence on formula.

Free samples of infant formula have been provided to hospitals since the 1930s, which practice has been criticized continuously since then; further, infant formula is the only product routinely provided free of charge to hospitals.[74]
[edit] United States

* In the United States, infant formula is heavily marketed – both in advertising to mothers and doctors and via free samples – in violation of the principles in the code, which has not been adopted or implemented by manufacturers in the US for US marketing.

In surveys, over 70% of large hospitals dispense infant formula to all infants, which is opposed by the AAP and in violation of the code.[75]

The American Academy of Pediatrics opposes marketing of infant formula directly to the public.[75]

The Gerber Products Company began marketing Gerber Baby Formula directly to the public in October 1989, while the Carnation Company began marketing Good Start infant formula directly to the public in January 1991.[75]
[edit] United Kingdom

In the United Kingdom, infant formula advertising has been illegal since 1995,[76] but advertising for follow-on formula is legal, which has been cited as a loophole allowing advertising of similarly-packaged formula, and is confusing to mothers.[38]
[edit] By country
Wiki letter w.svg This section requires expansion.
[edit] Philippines

Infant formula is a major product in the Philippines – it is one of the top three consumer commodities, and among the most imported products.[77]

Infant formula marketing has been regulated since the 1987 Executive Order 51 or "Milk Code".[22] This regulated but did not ban practices such as advertising and providing free samples. Shortly after it was enacted, Wyeth introduced follow-on formula, which was not in the purview of the Milk Code, follow-on formula not having existed at the time of the writing of the Milk Code.

In 2006, the Department of Health banned the advertising of infant formula and the practice of providing free samples, regardless of intended age group (in regulation RIRR), which regulation was challenged by the infant formula industry in the Supreme Court. Initially the challenge was dismissed, but this decision was immediately reversed, following a letter[78] by American business leader Thomas Donahue, then President and CEO of the United States Chamber of Commerce,[79] resulting in the regulation being suspended and advertising continuing.[22] [77]

In the Philippines annual sales amount to some US$469 million annually. US$88 million is spent on advertising the product.[80]
[edit] Canada

Vitamin D deficiency is a health concern in Canada. Infant formulas marketed in Canada are fortified with Vitamin D. Health Canada recommends that breastfed infants also receive extra vitamin D in the form of a supplement.[81] With the exception of vitamin D, vitamin and mineral supplementation of breastfed term infants in the first 6 months is not recommended unless a mother is a vegan.[81] Infant formulas marketed in Canada have not been tested for the presence of phthalates, a chemical used in the production of plastics, though concerns have been raised by Great Britain. Unlike other countries (e.g. New Zealand, UK) who have banned the general use of soy-based infant formula, it is still allowed in Canada. It is estimated that 20% of infants in Canada are fed soy beased infant formula and thus exposed to levels of phytoestrogen up to 22000 times higher than those normally found in breast milk, which gives the potential to damage a baby's thyroid.[82]
[edit] Infant Formula Processing
[edit] History of Infant Formula Development
Dates Events
1867 Formula contains wheat flour, cow milk, malt flour, and potassium bicarbonate [83]
1915 Powder form of infant formula was introduced. Formula contained cow milk, lactose, oleo oils, and vegetable oils [83]
1929 Soy formula was introduced [83]
1935 Protein was introduced into the infant formula. Protein was added because it was believed that cow-milk protein content was lower than human-milk protein content. 3.3–4.0 g/100 kcal of proteins were added.[83]
1959 Iron fortification was introduced because a large amount of iron (~80%) will be used to expand the red blood cell mass in a growing infant. Infants with birth weights between 1500 and 2500g require 2 mg/kg of iron per day. Infants with weights of less than 1500g require 4 mg/kg per day.[83][84]
1962 Whey : Casein ratio was made similar to human milk because producers were aware that human milk contain a higher content of whey protein and cow milk contain a higher content of casein.[83]
1984 Taurine fortification introduced because new born infants lack the enzymes needed to convert and form taurine.[83][85]
Late 1990 Nucleotide fortification was introduced into infant formula because nucleotide can act as growth factors and may enhance the immune system in infant’s body.[83]
Early 2000 Polyunsaturated fatty-acid fortification was introduced. Polyunsaturated fatty-acids, such as Docosahexaenoic acid (DHA) and Arachidonic acid (ARA), were added because those fatty-acids play an important role in infant’s brain development.[83]
[edit] Current general procedure for infant formula processing

The manufacturing process may differ for different types of formula made; therefore the following is the general procedure for liquid-milk based formulas:[33]
[edit] Mixing ingredients

Primary ingredients are blended in large stainless steel tanks and skim milk is added and adjusted to 60°C.Then, fats, oils and emulsifiers are added next. Additional heating and mixing may be required to get proper consistency. Next, minerals, vitamins, stabilizing gums are added at various points depending on their sensitivity to heat. This batch is temporarily stored and then transported by pipelines to pasteurization equipment when mixing is complete.[33]
[edit] Pasteurization

This is a process that protects against spoilage by eliminating bacteria, yeasts and molds. It involves quickly heating and then cooling of the product under controlled conditions which micro-organisms cannot survive. The batch is held at around 85-94°C for approximately 30 seconds which is necessary to adequately reduce micro-organisms and prepare the formula for filling.[33]
[edit] Homogenization

This is a process which increases emulsion uniformity and stability by reducing size of fat and oil particles in the formula. It is done with a variety of mixing equipment that applies shear to the product and this mixing breaks fat and oil particles into very small droplets.[33]
[edit] Standardization

Standardization is used to ensure that the key parameters like pH, fat concentration and vitamins and mineral content are correct. If insufficient levels of these are found, the batch is reworked to achieve appropriate levels. After this step, the batch is ready to be packaged.[33]
[edit] Packaging

Packaging depends on manufacturer and type of equipment used but in general liquid formula filled into metal cans w/ lids crimped into place.[33]
[edit] Heat Treatment/Sterilization

Finally, infant formulas are heat treated to maintain the bacteriologic quality of the product. This can be done traditionally by either retort sterilization or high-temperature short-time (HTST) treatment. Recently Ultrahigh-temperature treated formula has become more commonly used. If powdered formula is made, then an additional spray drying would be required after this.[86] Retort sterilization is a traditional retort sterilization method that uses 10-15mins treatment at 118°C.[86] Ultrahigh-temperature (UHT) is a method that uses a brief (2–3 seconds) treatment at 142°C. Because of the short time used, there is little protein denaturation but still ensures sterility of the final product.[86]
[edit] Recent and future potential new ingredients
[edit] Probiotics

Recently, probiotics have become a new ingredient in many of our foods and studies have been completed regarding the use of probiotics in infant formula [87] Several randomized controlled trials completed recently have shown limited and short term clinical benefits for the use of probiotics in infants’ diet [87] The safety of probiotics in general and in infants, especially preterm infants, has been investigated in a limited number of controlled trials. The findings this far suggests that probiotics are generally safe.[87] Therefore, the study suggested that more scientific research is necessary before a conclusion can be made about probiotic supplementation in infant formula since the research is still quite preliminary.[87]
[edit] Prebiotics

Prebiotics are nondigestable carbohydrates that promote the growth of probiotic bacteria in the gut. Human milk contains a variety of oligosaccharides that are believed to be an important factor in the pattern of microflora colonization of breastfed infants. Because of variety, variability, complexity and polymorphism of the oligosaccharide composition and structure, it is currently not feasible to reproduce the oligosaccharide components of human milk in a strictly structural fashion.[88]

The European Society of Pediatric Gastroenterology, Hepatology, and Nutrition Committee on Nutrition found evidence to support short term effects of ingesting prebiotics on stool microflora of infants with increased in the number of bifidobacteria. Babies can be at risk of dehydration with the induction of softer stools, if they have the kidney immaturity and/or a poor ability to concentrate urine.[88] A reduction of pathogens has been associated with the consumption of prebiotics.[88] However, there was no evidence to support major clinical or long-term benefits.[87] Therefore, there is little evidence in favor of beneficial effects of prebiotics in dietary products.[87]
Lysozyme and Lactoferrin

Lysozyme is an enzyme that is responsible for protecting the body by damaging bacterial cell walls. Lactoferrin is a globular, multifunctional protein that has antimicrobial activity. Comparing with human milk, cow’s milk has a signifactly lower levels of lysozyme and lactoferrin; therefore, the industry has an increasing interest in adding them into infant formulas.[83]
swenova mama
Sveta krava
Postovi: 7219
Pridružen/a: 11 tra 2001, 23:50


PostPostao/la swenova mama » 18 kol 2010, 23:07

zeljela bih zavrsiti jednom s raspravom oko toga zasto je ad mlijeko bolje za dijete od kravljeg, a svako malo na pdf-u iskoce postovi u kojima pise "pa i nas su hranili kravljim i nu nas, zivi, zdravi i veseli".
Pa prije takvih pausalnih tvrdnji voljela bih da se procita razvoj formule za bebe i zasto je bolja za djecu od kravljeg mlijeka. :mah
swenova mama
Sveta krava
Postovi: 7219
Pridružen/a: 11 tra 2001, 23:50


PostPostao/la nevenera » 08 svi 2015, 15:07

idejni kreator MUD-a
Postovi: 39246
Pridružen/a: 03 kol 2008, 14:18

Re: Sve o adaptiranom mlijeku

PostPostao/la nevenera » 08 svi 2015, 15:36

Mora li moje dijete popiti cijeli sadržaj bočice?
Djetetov apetit se mijenja i svako dijete ima svoje potrebe. Količine koje su spomenute na pakiranju su one koje u prosjeku odgovaraju najvećem broju djece. Ostatak u bočici Vas ne treba zabrinjavati. Višak mliječne formule koji ostane u bočici nakon obroka se mora baciti.

Koliko je dovoljno?
Stomak novorođene bebe može da primi 1 ili 2 kafene kašičice (5 do 10ml); a zatim sve više i više nakon prve nedelje. Trideset do 60 grama po obroku je obično dovoljno na početku. Ali u vreme kada Vaša beba napuni dva meseca, trebaće joj 680 do 900 grama dnevno i oko šest do sedam obroka u periodu od 24 časa.

Evo grube predstave koliko je adaptiranog mleka potrebno Vašoj bebi i koliko često je potrebno da je hranite:
Doba Količina po obroku Koliko često
Novorođenče 60 do 90 mililitara Svakih 3 do 4 sata
Jedan mesec 120 mililitara Svaka 4 sata
Dva meseca 120 mililitara 6 do 7 hranjenja/24 časa
Četiri meseca 120 do 180 mililitara 6 hranjenja/24 časa
Šest meseci 180 do 230 mililitara 5 hranjenja/24 časa
Jedna godina 230 mililitara 2 do 3 hranjenja/24 časa

Zapamtite, svaka beba je jedinstvena i kod svake bebe će unos hrane varirati od obroka do obroka, iz dana u dan. Nikada je ne hranite na silu, ali isto tako nemojte prestati da je hranite ukoliko ona želi još. Bebu koja često zna da ispljune hranu je bolje hraniti manjim a češćim obrocima. Pratite njene potrebe.

Evo kako još možete proceniti potrebnu količinu hrane za Vašu bebu:
Obezbedite 150 ml mleka na svaki bebin kilogram, kao količinu koja zadovoljava dnevne potrebe.
Posle prvog meseca, svakog sledećeg treba povećati ishranu za 30 ml po obroku. Počevši od 90 do 120 ml po obroku. Ovo povećavanje prestaje kada se dostigne količina od 240 ml po obroku.

Kada Vaša beba ima manje od 3 meseca potrebne su Vam male bočice od 120 ml kako biste je nahranili. Nešto kasnije, biće vam potrebna veća boca, od 240 ml.

Adaptirano mleko se sporije vari od majčinog mleka, zato očekujte da pauze između hranjenja budu nešto duže (tri do četiri sata) i da stolica bude nešto obimnija i suvlja od one koju je beba imala dok je sisala majčino mleko.


Bočice i dudice se moraju nakon svakog korištenja temeljito oprati i spremiti na suho i čisto mjesto.
1. Nakon svakog obroka bočice i poklopce oprati četkicom za pranje.
2. Silikonske dudice oprati sredstvom za pranje i i detaljno isprati.
3. Gumene dudice prokuhati (kod silikonskih dudica to nije potrebno)
4. Obrisati dudice čistim ručnikom i spremati u zatvoreni spremnik do sljedećeg korištenja. Potrebno je redovito kontrolirati dudice jer gumene dudice mogu biti porozne. Ugrizi i ogrebotine na silikonskim dudicama znak su oštećenja. Plastične žličice koje se dobiju uz mliječnu formulu nemojte prati u perilici suđa. Ukoliko ih je potrebno oprati isperite ih vodom i dobro posušite. Ukoliko je došlo do oštećenja žličice, nemojte ju više koristiti.
idejni kreator MUD-a
Postovi: 39246
Pridružen/a: 03 kol 2008, 14:18

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